Question On the topic of organ donation...

I've been searching through the forum and the WIKI for hours on end! (Okay, that's not really true)

I had a small thought about what would happen if a baseline happened to get an organ or more from a mutant implanted into them?

Would the organs be rejected? Would the presumably stronger genetics from the mutant begin overriding the recipient? As if wit a high level exemplar or perhaps a regenerator?

How would the BIT influence the recipient? If at all?

Or...would nothing happen?

MID holders are bared from donating their organs for transplant. They can, however, donate their remains to certain scientific research institutes for study.

Oh sure. Known mutants wouldn't be allowed to donate blood or organs. But as we've seen in a couple of stories, not all mutants are known or even obvious mutants.

With Knockoff we've seen what could happen with regards to a blood transfusion from a regenerator. But what about with organs?

It's a good question... We've seen that BITs are individual to each, well, individual. And we've shown some BIT copying experiments...

I would say, and take this with a grain of salt as I'm neither a Physician nor a Devisor/Gadgeteer... The organs transplanted would be removed from the individual and retain their physical structure but not translate the BIT ordinarily unless some power (regeneration for instance) were to act upon the organ.

How this, hypothetical, organ would react is certainly a field of study that someone could enter but would be crossing some ethical and legal boundaries.

There is the issue as to whether a regeneration factor is biochemical, psychokinetic or magical.

BUT, for more to the point, there is the issue that MUTANT tissue is noticeably different from baseline tissue, and the rejection factor would be a quantum shift higher

"Fear my super-spleen!"

There would certainly be issues of whether you gave someone baseline organs or tissue that is too efficient. Even if they aren't a high enough regen for regen-cloning, imagine if someone got exemplar bone marrow was too good, and produced too much blood, too rapidly. In a lower to mid level exemplar, that increased production might be alright for them. But for a baseline, yikes.

Or how about a skin transplant from an Exemplar with a greater than normal resistance to damage.

Let's say, hypothetically, that the recipient's system didn't reject it. Would that person then be resistant to damage as well, or would the skin's "damage resistance" deteriorate over time becoming just regulare baseline level (or perhaps slightly above that)?
Or would it, due to "stronger DNA" start changing the person? (probably with a plethora of diseases though) Hell, you could argue that it would make it difficult for the baseline recipient to move around?

Rose Bunny wrote: "Fear my super-spleen!"

There would certainly be issues of whether you gave someone baseline organs or tissue that is too efficient. Even if they aren't a high enough regen for regen-cloning, imagine if someone got exemplar bone marrow was too good, and produced too much blood, too rapidly. In a lower to mid level exemplar, that increased production might be alright for them. But for a baseline, yikes.

Ideally, the existing feedback mechanisms would just cycle the production on for less time. Otherwise, that could be a fast track to leukemia.

Fun trivia fact: Body makes X amount of clotting factors. A mild overproduction of platelets increases clotting, and the risk of clots forming where they don't need to be, because there's enough clotting factor to do that. A severe overproduction of platelets can exhaust the supply and lead to excess bleeding. Either way, a mere baseline spleen is going to be unhappy.

Written somewhere (possibly the Bible, but I'm not going to dig for it) and which I used as subject material for Knockoff, is that anyone over a regen-3 can NOT be a blood donor due to risk of regen cloning (which is usually fatal in a very messy way). Note the clinic discussions with Setup and the doc about her regen level...

There's all sorts of issues with donation from regens to non-regens. There are some early mentions in canon which are a homage to a Morpheus story (A Change of Heart, the second story in his Legacy universe). Later, there was a bit more discussion of the issue in the later Jade stories, after she gets regen. And then there's the Knockoff origin story by ElrodW, which also delves on it.

Sir Lee wrote: There's all sorts of issues with donation from regens to non-regens. There are some early mentions in canon which are a homage to a Morpheus story (A Change of Heart, the second story in his Legacy universe). Later, there was a bit more discussion of the issue in the later Jade stories, after she gets regen. And then there's the Knockoff origin story by ElrodW, which also delves on it.

A minor point that's only slightly off-topic: In Gen 2, there's no mention of the work done on understanding the genetic expression of Regen.

It could be that this hasn't been enough time for the research side of the work to be completed, but is there a Canon background to this dangling plot-thread?

In Universe: You can figure some work has been done, but it's still fairly low key, hitting into various bioethical research considerations, plus *how do you prove* it points.

Out of universe: Really hadn't thought about it, but generally, between typical bioethical rules, and H1, and all that jazz, it's not going as fast as it could, plus, Healers do exist, so some of the pressures are off for that type of research.

MageOhki wrote: In Universe: You can figure some work has been done, but it's still fairly low key, hitting into various bioethical research considerations, plus *how do you prove* it points.

Out of universe: Really hadn't thought about it, but generally, between typical bioethical rules, and H1, and all that jazz, it's not going as fast as it could, plus, Healers do exist, so some of the pressures are off for that type of research.

Fair enough.

Yes, realistically it would take decades IRL, AND, it would be a MAJOR divergence between the background universe, and the WU.

It would also be a plot-thread for the Kimba characters, and the Gen 1 authors.

Just wondering, was all.

Let me put it that way: BioRegenetics research on induced regen began in late 2006. It takes a few years to crack the problem of inducing regen without overwriting the entire genome of the patient. Then there's in-vitro testing, then there's animal testing...
I guess that at some point the Gen2 authors might use the start of human testing as a plot point. And, for story plot points, the usefulness of the research might be different depending on whether the patient has an active MGC, an inactive MGC or no MGC. Meaning: will it work in mutants? Will it work in baselines? Will it work in baselines with an inactive MGC, but trigger its activation? Will it have different side effects in mutants and non-mutants? All interesting possibilities.

Of course the assumes it works in a reasonable time,or even works at all.
There are an awful lot of bio solutions that look good at first test, then collapse horribly once investigated properly.

Other considerations include interactions with other substances (alcohol, caffeine, nicotine, aspirin, rittalin, prozac, viagra, birth control...), what effects it has on pregnancy, whether it fucks over your sexual partners, and how safe it is over the course of decades (possibly many decades if it slows aging).

You made me think of this: